Immune Desert CD4 Macrophage Bias

Archetype Feature Distributions
Tcells  Myeloid  Stromal  Treg   CD4 Tcells   CD8 Tcells Monocytes  Macrophages  cDC2 cDC1
Low Variable High Low Variable Low Low Very High Variable Low

 


Potential Origin of this Archetype

Central Nervous System, Tissue resident T cells, Macrophage Axis, Sustained by CXCR2 signalling

Archetype Tumor transcriptomic program

Cell cycle (G1-S), Nervous system

Archetype Chemokines Expressed

CXCl17, CCR6, CXCL1, CXR2

Archetype Immune Transcriptomic Programs

Tissue resident T cells (Trem), Th17 like, IL10, TNFa, IL1 Signalling


Immune Archetype Gene Signature 

Table of Archetype Feature Scores

Table of Archetype feature flow Populations         

Table of Archetype non feature flow Populations


Histology Abbreviations

ADC = Adenocarcinoma NOS    PSC = Papillary  Serous Cystadenocarcinoma   PC = Papillary  Carcinoma  C = Carcinoma NOS  SC = Small Cell Carcinoma NOS  CCC = Clear Cell Carcinoma NOS   EA = Endometriod Adenocarcinoma  NET = Neuroendocrine Tumor  TCC = Transitional Cell Carcinoma NOS, MES = Mesothelioma Malignant MA = Mucinous Adenocarcinoma  G= Glioblastoma, NOS

 
SampleGenderRaceEthnicityBMIAgeT StageN StageM StageGradeHistologyTumor typeExtraction Site
IPIBLAD033.T1MaleWhiteNon Hispanic or Latino29621a0 G3: Poorly differentiated (high grade)TCCRegional RecurrenceBladder
IPICRC067.T1FemaleWhiteNon Hispanic or Latino32.4953100G2: Moderately differentiated (intermediate grade)ADCPrimarysigmoid colon
IPICRC071.T2MaleWhiteNon Hispanic or Latino37.7654 01G2: Moderately differentiated (intermediate grade)ADCLocalRecurrence 
IPICRC073.T1FemaleOtherHispanic or Latino24.87504a0 GX: Grade cannot be assessed (undetermined grade)ADCPrimarysigmoid colon
IPICRC076.T1MaleWhiteNon Hispanic or Latino21.61574b1 G1: Well differentiated (low grade)ADCPrimaryrectosigmoid junction
IPICRC078.T2FemaleWhiteNon Hispanic or Latino22.8958Not AvailableNot AvailableNot AvailableG1: Well differentiated (low grade)NETPrimarycolon
IPIGBM006.T1FemaleWhiteNon Hispanic or Latino27.8254Not AvailableNot AvailableNot AvailableG4: Undifferentiated (high grade)GPrimaryright frontal lobe
IPIGYN015.T1FemaleOtherNon Hispanic or Latino15.44471c0 G2: Moderately differentiated (intermediate grade)EALocalRecurrenceovary
IPIGYN019.T1FemaleOtherHispanic or Latino37.4593cX G3: Poorly differentiated (high grade)CPrimaryovary
IPIGYN021.T1FemaleWhiteNon Hispanic or Latino23.41662c1 G3: Poorly differentiated (high grade)PSCPrimary 
IPIGYN040.T1FemaleOtherHispanic or Latino41.33661a0 G2: Moderately differentiated (intermediate grade)EAPrimary 
IPIGYN043.T1FemaleWhiteNon Hispanic or Latino50.63381aX G1: Well differentiated (low grade)EAPrimaryuterus
IPIGYN060.T1FemaleWhiteNon Hispanic or Latino27.05542a0 G3: Poorly differentiated (high grade)PSCPrimaryovary
IPIGYN083.T1FemaleWhiteHispanic or Latino33.62611aX G1: Well differentiated (low grade)EAPrimaryuterus
IPIGYN091.T1FemaleWhiteNon Hispanic or Latino3354Not AvailableNot AvailableNot AvailableG3: Poorly differentiated (high grade)MAMetastasisovary
IPIGYN093.T1FemaleOtherHispanic or Latino46313aX G1: Well differentiated (low grade)EAPrimaryuterus
IPIGYN095.T1FemaleOtherNon Hispanic or Latino3153Not AvailableNot AvailableNot AvailableNot AvailableMAPrimarypelvic region element
IPIGYN098.T1FemaleWhiteNon Hispanic or Latino1856Not AvailableNot AvailableNot AvailableNot AvailableDenuded benign cystPrimaryuterus
IPIGYN103.T1FemaleWhiteNon Hispanic or Latino48601a0 G1: Well differentiated (low grade)EAPrimaryuterus
IPIGYN106.T1FemaleWhiteNon Hispanic or Latino33603b0 G3: Poorly differentiated (high grade)EAPrimary 
IPIGYN107.T1FemaleOtherHispanic or Latino25392X G3: Poorly differentiated (high grade)CPrimaryuterus
IPIGYN108.T1FemaleWhiteNon Hispanic or Latino27701a0 G1: Well differentiated (low grade)EAPrimaryuterus
IPIGYN116.T1FemaleAmerican Indian or Alaskan NativeNon Hispanic or Latino32692a0 G3: Poorly differentiated (high grade)OSCPrimaryfallopian tube
IPIGYN125.T1FemaleWhiteNon Hispanic or Latino41621b10G1: Well differentiated (low grade)EAPrimaryuterus
IPIHNSC069.T1MaleAsianNon Hispanic or Latino37.6647200G3: Poorly differentiated (high grade)ADCPrimarymajor salivary gland
IPIKID062.T1MaleWhiteNon Hispanic or Latino30663aX G3: Poorly differentiated (high grade)CCCPrimaryright kidney
IPIKID067.T1FemaleWhiteHispanic or Latino27803a0 GX: Grade cannot be assessed (undetermined grade)CCCPrimaryright kidney
IPIKID073.T1MaleWhiteNon Hispanic or Latino30601a0 G1: Well differentiated (low grade)PCPrimaryleft kidney
IPIKID110.T1MaleWhiteNon Hispanic or Latino24722b1 G4: Undifferentiated (high grade)OtherPrimaryright kidney
IPILUNG049.T1MaleAsianNon Hispanic or Latino275532 Not AvailableMESPrimaryleft lung
IPILUNG055.T1FemaleWhiteNon Hispanic or Latino29701b0 G3: Poorly differentiated (high grade)SCLocalRecurrencelower lobe of left lung