Immune Rich CD4 Macrophage Bias | The UCSF Data Library

Archetype Feature Distributions

Tcells	Myeloid	Stromal	Treg	CD4 Tcells	CD8 Tcells	Monocytes	Macrophages	cDC2	cDC1
Variable	Variable	Low	High	High	Low	Low	Variable	High	Low

Potential Origin of this Archetype

Epithelial homestasis in the Stromal Treg axis sustained by IFN/CCR2 TGFb

Archetype Tumor transcriptomic program

ER Stress (CH25H, ERN2)

Archetype Chemokines Expressed

CCL17, CCL18, CCR4, CCR8

Archetype Immune Transcriptomic Programs

TGFb signaling , enriched in DC3 anfd resting Tregs

Immune Archetype Gene Signature

Table of Archetype Feature Scores

Table of Archetype Feature Flow Populations

Table of Archetype non feature Flow Populations

Histology Abbreviations

ADC = Adenocarcinoma NOS PC = Papillary Carcinoma NOS C = Carcinoma NOS CCC = Clear Cell Adenocarcinoma NOS


Sample	Gender	Race	Ethnicity	BMI	Age	T Stage	N Stage	M Stage	Grade	Histology	Tumor type	Extraction Site
IPIBLAD026.T1	Male	Other	Non Hispanic or Latino	31	61	1	0	X	G3: Poorly differentiated (high grade)	Clear Cell Adenocarcinoma NOS	Primary	Ureter
IPICRC087.T1	Female	White	Non Hispanic or Latino	17.83	70	3	0		G2: Moderately differentiated (intermediate grade)	ADC	Primary	ascending colon
IPICRC088.T1	Male	Asian	Non Hispanic or Latino	16.64	83	4a	2	1	G2: Moderately differentiated (intermediate grade)	ADC	Primary	ascending colon
IPICRC090.T1	Male	White	Non Hispanic or Latino	25.9	36	3	1b		G2: Moderately differentiated (intermediate grade)	ADC	Primary	rectum
IPIGYN013.T1	Female	Asian	Non Hispanic or Latino	19.66	59	1	0		G3: Poorly differentiated (high grade)	CCC	Primary	ovary
IPIKID108.T1	Male	Asian	Non Hispanic or Latino	27	54	3b	0		G3: Poorly differentiated (high grade)	PC	Primary	right kidney
IPILUNG008.T1	Female	White	Non Hispanic or Latino	20	72	1a	0		G1: Well differentiated (low grade)	ADC	Primary	upper lobe of right lung
IPILUNG013.T1	Male	White	Non Hispanic or Latino	22	80	1b	1		G2: Moderately differentiated (intermediate grade)	ADC	Primary	upper lobe of left lung
IPILUNG014.T1	Female	Black or African American	Non Hispanic or Latino	20	81	1b	1		G3: Poorly differentiated (high grade)	ADC	Primary	upper lobe of left lung
IPILUNG015.T1	Male	White	Non Hispanic or Latino	28	83	1a	0		G2: Moderately differentiated (intermediate grade)	ADC	Primary
IPILUNG030.T1	Female	Other	Non Hispanic or Latino	39	61	1b	0		G3: Poorly differentiated (high grade)	ADC	Primary
IPILUNG041.T1	Female	Asian	Non Hispanic or Latino	28	79	2a	2		G2: Moderately differentiated (intermediate grade)	ADC	Primary	lower lobe of right lung
IPILUNG054.T1	Female	White	Non Hispanic or Latino	33	76	1a	X		G2: Moderately differentiated (intermediate grade)	ADC	Primary	upper lobe of right lung
IPILUNG058.T1	Male	White	Non Hispanic or Latino	30	75	1b	X		G2: Moderately differentiated (intermediate grade)	ADC	Primary	upper lobe of left lung
IPILUNG069.T1	Male	White	Non Hispanic or Latino	27	63	1b	2		G3: Poorly differentiated (high grade)	ADC	Primary	upper lobe of right lung
IPILUNG076.T1	Female	Asian	Non Hispanic or Latino	20	59	2a	0		G2: Moderately differentiated (intermediate grade)	ADC	Primary	upper lobe of right lung
IPILUNG080.T1	Male	Asian	Non Hispanic or Latino	25	69	2a	1		G3: Poorly differentiated (high grade)	ADC	Primary	lower lobe of right lung
IPIMEL252.T1	Male	White	Non Hispanic or Latino	18	61	3b	3	0	Not Available	Nevi & Melanomas	Primary	right arm
IPIMEL253.T1	Male	White	Non Hispanic or Latino	30	62	4b	X	1c	Not Available	Nevi & Melanomas	Metastasis	retroperitoneal lymph node
IPIMEL255.T1	Male	White	Non Hispanic or Latino	36	48	4b	2	0	Not Available	Nevi & Melanomas	Metastasis	Left axilla, sentinel lymph node