Immune Rich CD8 Macrophage Bias | The UCSF Data Library

Archetype Feature Distributions

Tcells	Myeloid	Stromal	Treg	CD4 Tcells	CD8 Tcells	Monocytes	Macrophages	cDC2	cDC1
High	High	Low	Variable	Low	High	Variable	Very High	Low	High

Potential Origin of this Archetype

Chronic inflamation in CD8 Tcells Macrophages sustained by IFN signaling
Chronic viral infection

Archetype Tumor transcriptomic program

IFN/CSF1 Signalling

Archetype Chemokines Expressed

CXCL9, CXCL11, CXCL12, CXCR3, CXCR4, XCL1, XCL2, XCR1

Archetype Immune Transcriptomic Programs

Type 1 Immunity (M1 and Th1), High in Nk cells, High Exhaustion, IFN/TNFa signalling, PD1-PDL1/2

Immune Archetype Gene Signature

Table of Archetype Feature Scores

Table of Archetype Feature flow Populations

Table of Archetype NON FEATURE flow Populations

Histology Abbreviations

ADC = Adenocarcinoma NOS PSC = Papillary Serous Cystadenocarcinoma PC = Papillary Carcinoma SCC = Squamous Cell Carcinoma CCC = Clear Cell Carcinoma NOS EA = Endometriod Adenocarcinoma BS = Benign schwannoma

Table of Archetype Clinical Data
Sample	Gender	Race	Ethnicity	BMI	Age	T Stage	N Stage	M Stage	Grade	Histology	Tumor type	Extraction Site
IPICRC058.T1	Female	White	Non His/Lat	30.04	88	3	0	0	G2	ADC	Local Recurrence	colon
IPICRC062.T1	Female	White	Non His/Lat	30.43	86	3	0	0	G1	ADC	Primary	colon
IPICRC089.T1	Male	White	Non His/Lat	21.47	40	NA	NA	NA	NA	BS	Primary	retroperitoneum
IPIGYN084.T1	Female	White	Non His/Lat	26.99	75	3a	X		G3	PSC	Primary	abdominal wall
IPIGYN100.T1	Female	Other	His/Lat	41	53	1a	0		G1	EA	Primary	uterus
IPIKID027.T1	Male	White	Non His/Lat	29	79	3a	X		G2	CCC	Primary	right kidney
IPIKID030.T1	Male	Other	His/Lat	28.8	59	3a	X		G3	CCC	Primary	right kidney
IPIKID043.T1	Male	White	Non His/Lat	25.9	79	2a	1		G3	PC	Primary	right kidney
IPIKID047.T1	Female	White	Non His/Lat	22.4	73	3a	X		GX	Other	Primary	right kidney
IPIKID048.T1	Female	Asian	Non His/Lat	27.5	59	4	1		G4	CCC	Primary	right kidney
IPIKID050.T1	Male	White	Non His/Lat	22.9	89	4	X		G3	PC	Primary	right kidney
IPIKID051.T1	Male	White	Non His/Lat	27.3	63	3b	0	X	G4	CCC	Primary	right kidney
IPIKID066.T1	Male	White	Non His/Lat	41	68	2a	X		G3	CCC	Primary	right kidney
IPIKID074.T1	Male	White	Non His/Lat	28	68	3a	X		G3	CCC	Primary	right kidney
IPIKID076.T1	Male	White	Non His/Lat	26	68	3a	0		G4	CCC	Primary	right kidney
IPIKID078.T1	Male	Asian	Non His/Lat	33	63	3a	0		G4	CCC	Primary	right kidney
IPIKID079.T1	Male	White	Non His/Lat	32	73	1a	X		G1	PC	Primary	right kidney
IPIKID083.T1	Male	Asian	Non His/Lat	25	42	2a	0		G3	CCC	Primary	left kidney
IPIKID084.T1	Female	White	Non His/Lat	41	49	2a	X		GX	CCC	Primary	kidney
IPIKID086.T1	Male	White	Non His/Lat	34	69	3a	0		G3	CCC	Primary	left kidney
IPIKID091.T1	Male	White	Non His/Lat	28	74	3a	X		G4	CCC	Primary	right kidney
IPIKID092.T1	Male	Other	Non His/Lat	35	64	3a	X		G4	CCC	Primary	right kidney
IPIKID093.T1	Female	Other	Non His/Lat	36	65	3a	0		G3	CCC	Primary	right kidney
IPIKID099.T1	Male	White	Non His/Lat	25	55	1a	X		G3	CCC	Primary	left kidney
IPIKID100.T1	Female	Asian	His/Lat	30	79	3b	X		G2	CCC	Primary	right kidney
IPIKID102.T1	Male	Other	His/Lat	29.8	60	3b	0		G2	CCC	Primary	right kidney
IPILUNG006.T1	Female	Asian	Non His/Lat	24	66	1a	0		G2	ADC	Primary	right lung
IPILUNG031.T1	Male	Asian	Non His/Lat	22	60	2b	2		GX	SCC	Primary	right lung
IPIMELB002.T1	Female	Other	Not reported	20	76	NA	NA	NA	NA	NA	Metastasis	Pancreas